Author

F. Sedighi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Adegbuyiro· 1 shared A. Skeens· 1 shared C. Siriwardhana· 1 shared E. Donley· 1 shared J. Bard· 1 shared J. Legleiter· 1 shared W. J. Geldenhuys· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Adegbuyiro

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1 paper

Recent·Most cited

Oligomerization enhances huntingtin membrane activity but is suppressed by covalent crosslinking

F. Sedighi, A. Skeens, A. Adegbuyiro, J. Bard, C. Siriwardhana, E. Donley, W. J. Geldenhuys, J. Legleiter

This study investigates how different aggregation states of huntingtin interact with lipid membranes and finds that oligomers are the most active, but covalent crosslinking suppresses their membrane binding and toxicity.

bioRxiv · Mar 1, 2023 · PreprintBiophysics