Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations
A. Kafkova, L. Tilokani, F. Trcka, V. Sramkova, M. Vancova, T. Bily, J. Nebesarova, J. Prudent, J. Trnka
This study shows alkyl-TPP reversibly alters mitochondrial morphology and function, selectively decreasing inner membrane proteins and cleaving Optic atrophy-1, with effects not due to membrane potential loss.
bioRxiv · Mar 9, 2021Biochemistry