An intact S-layer is advantageous to Clostridioides difficile within the host.
M. J. Ormsby, F. Vaz, J. A. Kirk, A. Barwinska-Sendra, J. C. Hallam, P. Lanzoni-Mangutchi, J. Cole, R. R. Chaudhuri, P. S. Salgado, R. P. Fagan, G. Douce
This paper shows that an intact S-layer in Clostridioides difficile enhances disease severity by analyzing revertants of an S-layer-null strain and their gene expression differences.
bioRxiv · Nov 22, 2022 · PreprintMicrobiology