Author

G. Douce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Brown· 2 shared A. Barwinska-Sendra· 1 shared A. M. Buckley· 1 shared A. Ridyard· 1 shared A. S. Walker· 1 shared A. Shaw· 1 shared C. A. Marwick· 1 shared C. Albuquerque· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

D. Brown

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Author profile →

5 papers

Recent·Most cited

An intact S-layer is advantageous to Clostridioides difficile within the host.

M. J. Ormsby, F. Vaz, J. A. Kirk, A. Barwinska-Sendra, J. C. Hallam, P. Lanzoni-Mangutchi, J. Cole, R. R. Chaudhuri, P. S. Salgado, R. P. Fagan, G. Douce

This paper shows that an intact S-layer in Clostridioides difficile enhances disease severity by analyzing revertants of an S-layer-null strain and their gene expression differences.

bioRxiv · Nov 22, 2022 · PreprintMicrobiology

Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis

R. Kiu, A. Shaw, K. Sim, H. Bedwell, E. Cornwell, D. Pickard, G. Belteki, J. Malsom, S. Philips, G. Young, Z. Schofield, C. Alcon-Giner, J. Berrington, C. Stewart, G. Dougan, , L. J. Hall

This study identifies hypervirulent C. perfringens strains linked to NEC in preterm infants, showing their dissemination between hospitals and increased virulence.

bioRxiv · Aug 3, 2021 · PreprintMicrobiology

Insights into the regulatory mechanisms of Clostridioides difficile biofilm formation

A. M. Buckley, D. Ewin, I. Moura, M. Wilcox, G. Douce

This study investigates the transcriptional changes and regulatory pathways in Clostridioides difficile during biofilm formation, identifying metabolic reprogramming and small RNAs involved in biofilm regulation.

bioRxiv · Feb 19, 2021 · PreprintMicrobiology

The duration of antibiotic treatment is associated with carriage of toxigenic and atoxigenic strains of Clostridioides difficile in dogs.

C. Albuquerque, D. Pagnossin, K. Landsgaard, J. Simpson, D. Brown, J. Irvine, D. Candlish, A. Ridyard, G. Douce, C. Millins

This study investigates C. difficile carriage in dogs, finding that antibiotic use increases carriage, including toxigenic strains linked to human disease, but not necessarily causing diarrhoea in dogs.

bioRxiv · Jan 12, 2021Microbiology

A role for tetracycline selection in the evolution of Clostridium difficile PCR-ribotype 078

K. E. Dingle, X. Didelot, T. P. Quan, D. W. Eyre, N. Stoesser, C. A. Marwick, J. Coia, D. Brown, S. Buchanan, U. Z. Ijaz, C. Goswami, G. Douce, W. N. Fawley, M. H. Wilcox, T. E. Peto, , D. W. Crook

The paper investigates the evolutionary history of Clostridium difficile RT078, finding that tetracycline resistance genes, particularly tetM, were acquired independently in multiple clonal expansions, contributing to its increased prevalence.

bioRxiv · Feb 8, 2018Microbiology