AlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin Syndrome patients
A. Jane Bardwell, Umaima Arif, Fatima Muhammad, Celeste N. Salinas Auris, Lee Bardwell
The paper uses AlphaFold3 to predict GLI-SUFU complex structures, identifies binding-defective SUFU variants from patients, and validates their functional impact.
bioRxiv · Apr 20, 2026 · PreprintBiochemistry