A Novel PD-L1 Splice Isoform Modulates β Cell Communication in Response to Interferon Signaling
Chaitra Rao, Fei Huang, Saptarshi Roy, Matthew C. Austin, Matthew B Johnson, Kerim B. Kaylan, Irene Amalraj, A. G. de Oliveira, Decio Laks Eizirik, Carmella Evans‐Molina, Amelia K. Linnemann, Jon D. Piganelli, Richard A. Oram, Raghavendra G. Mirmira, Emily Kristen Sims
The paper identifies an IFN-induced PD-L1 splice variant, PD-L1Δ3, which is retained intracellularly and fails to suppress T cell activation, altering β cell immune communication in type 1 diabetes.
bioRxiv · Sep 28, 2026 · PreprintCell Biology