Fei Shao

Lack of ancestral SARS-CoV-2 imprinting promotes BA.3.2.2 infection in children

This study shows that the lack of ancestral SARS-CoV-2 immune imprinting in children makes them more susceptible to BA.3.2.2 infection, as it evades neutralizing antibodies typically present in adults.

Increased receptor binding capability of the SARS-CoV-2 saltational variant PJ.2.1

The paper shows that the SARS-CoV-2 variant PJ.2.1 has high ACE2-binding capability but limited immune evasion, suggesting structural changes that may enable future immune escape.

Antibody evasion and receptor binding of SARS-CoV-2 variants PQ.16.1.1 and RK.1

This study evaluates the antibody evasion and receptor binding of SARS-CoV-2 variants PQ.16.1.1 and RK.1, finding reduced ACE2 engagement but increased immune evasion.

Mouse V(D)J Humanization Recapitulates human-like Severe SARS-CoV-2 Immune Imprinting

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.