Weiliang Song

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

SARS-CoV-2 variant BA.3.2 strongly evades neutralizing antibodies but exhibits low infectivity due to a closed spike conformation, whereas NB.1.8.1 combines high ACE2 affinity with humoral immune escape.

The paper analyzes virological and antigenic traits of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1, finding trade-offs between immune evasion and ACE2 binding efficiency.

This study shows that SARS-CoV-2 variants KP.3.1.1 and XEC have enhanced immune evasion through NTD glycosylation, despite maintaining high ACE2 binding and infectivity.

This paper presents a non-invasive preimplantation genetic testing method using spent embryo culture medium, achieving high accuracy for monogenic and polygenic disease detection without modifying IVF workflows.

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

This study assesses the antigenic properties and immune evasion of the SARS-CoV-2 variant BA.2.87.1, finding it less resistant to neutralizing antibodies than JN.1 but with compensatory deletions in the NTD.

The paper introduces Cabernet, a bisulfite-free single-cell method for high-resolution 5mC and 5hmC profiling, revealing epigenetic dynamics in mouse embryos and demonstrating scalability for complex tissues.