Multiple Allosteric Sites Allow for Synergistic Enhancement of GPCR Signaling
Kai Wang, Snezana T. Dimova, John N. Hanson, Abhishek Thakur, Youwei Xu, Y.-F. Liu, Amy E. Moritz, Alexander Goldberg, Bing Xie, Jayachandra Rayadurgam, Feijun Wang, Ashley N. Nilson, Kathryn D. Luderman, R. Benjamin Free, Wen Hu, , Youwen Zhuang
The paper identifies multiple allosteric sites on the D1 dopamine receptor that allow synergistic enhancement of GPCR signaling through combined positive allosteric modulators.
bioRxiv · Oct 21, 2025 · PreprintMolecular Biology