Kai Wang

Decoding Cell-type Specific Gene Regulation with CellReg3D by Integrating DNA Large Language Models and 3D Genome Structure

CellReg3D integrates DNA language models and 3D genome structure to model cell-type-specific gene regulation, achieving state-of-the-art performance in predicting epigenetic marks and gene expression.

A durably colonizing engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

This paper develops a safety-optimised native E. coli strain for long-term gut colonisation and sustained therapeutic delivery, showing efficacy in treating colitis and metabolic dysfunction.

TCMCard: A High-Confidence Digital Infrastructure for Traditional Chinese Medicine Quantified by Multi-Dimensional Evidence Integration

TCMCard integrates multi-dimensional evidence to curate high-confidence TCM interaction data, improving network pharmacology analysis through noise reduction and functional module identification.

Glucose is a ligand-like trigger for secretion of postprandial GLP-1

This study shows glucose directly binds to glucokinase (GK) to trigger GLP-1 secretion in intestinal L cells, independent of ATP levels, and identifies GK and KATP as key players in this process.

TUPAD: A Tn5-Mediated, Pre-amplification/Adapter-Dimer-Free Platform for Ultra-Uniform, One-Step PGT Profiling with High Stability and Broad Compatibility

TUPAD is a new library preparation method for PGT that eliminates pre-amplification bias and improves CNV detection with high uniformity and reliability.

Multiple Allosteric Sites Allow for Synergistic Enhancement of GPCR Signaling

The paper identifies multiple allosteric sites on the D1 dopamine receptor that allow synergistic enhancement of GPCR signaling through combined positive allosteric modulators.

First Whole-Genome Chikungunya Virus Sequence Detected in Mosquitoes during the 2025 Foshan Outbreak: Evidence of Field Vector Infection and Transmission Potential in China

The paper reports the first whole-genome sequence of Chikungunya Virus (CHIKV) from mosquitoes during the 2025 Foshan outbreak, showing adaptation to Ae. albopictus and increased transmission potential.

Multiomics Reveals Compartmentalized Immune Responses and Tissue-Vascular Signatures in Lyme Disease

This study uses multiomic analysis to identify compartmentalized immune responses and tissue-vascular signatures in Lyme disease, linking local immune processes to systemic symptoms.

Inhibition of Posterior Thalamic Nuclei Attenuates CGRP-induced Migraine-like Behavior in Mice

This study shows that inhibiting the posterior thalamic nuclei in mice reduces CGRP-induced touch hypersensitivity and partially reduces light aversion, suggesting the PoT's role in migraine-like behaviors.

HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

This study identifies an HNF4-TET2-FBP1 axis that regulates gluconeogenesis and shows metformin's effect on this pathway in type 2 diabetes.

Large-scale population genomics of Malayan pangolins reveals deep diversification and a new species

This study reveals deep genetic differentiation in Malayan pangolins, identifies two new genetic populations, and proposes a new species closely related to the Philippine pangolin.

High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs

The paper identifies CNVs in KOLF2.1J iPSCs linked to neurological disorders, showing they arose in vitro and affect gene expression in neural cells.

Mapping the landscape of magnetic field effects on neural regeneration and repair: a systematic review, mathematical model, and meta-analysis

This paper evaluates how magnetic fields affect neural repair in vitro through systematic review, mathematical modeling, and meta-analysis, finding increased NPC proliferation and decreased astrocytic differentiation.

MetaRNN: Differentiating Rare Pathogenic and Rare Benign Missense SNVs and InDels Using Deep Learning

This paper introduces MetaRNN and MetaRNN-indel, deep learning models that differentiate rare pathogenic from benign variants, outperforming existing methods and providing interpretable scores.

Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones

This study develops a BBS10 knockout mouse model to investigate retinal degeneration, finding progressive loss of cone function and thinning of the outer nuclear layer.

Expanding the Phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome

The paper expands the phenotypic spectrum of NAA10 and NAA15-related neurodevelopmental syndromes by analyzing clinical data from 106 NAA10 and 66 NAA15 variant carriers, revealing variable severity and multi-system involvement.

Single-cell analysis reveals a pathogenic cellular module associated with early allograft dysfunction after liver transplantation

The paper constructs a single-cell transcriptomic atlas of transplanted livers and identifies an EAD-associated pathogenic cellular module.

Mouse Organ Specific Proteins and Functions

The paper examines organ-specific proteins in mice across different genetic backgrounds to assess their diversity and define robustness scores for quality assessment.

Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination

The paper identifies Tyr as the gene responsible for the Cctq1a QTL and shows that developmental light exposure interacts with genotype to influence central corneal thickness.

Detecting differential alternative splicing events in scRNA-seq with or without UMIs

SCATS detects differential alternative splicing in scRNA-seq data with or without UMIs, showing higher sensitivity than existing methods and validated by qRT-PCR.

DNA demethylation is a driver for chick retina regeneration

This study identifies DNA demethylation as a key driver of chick retina regeneration through RPE reprogramming, with TET3 playing a critical role in this process.

Cell type-specific proteogenomic signal diffusion for integrating multi-omics data predicts novel schizophrenia risk genes

The paper introduces a method to integrate multi-omics data for predicting schizophrenia risk genes by modeling proteogenomic signal diffusion across cell types and tissues.

Temporal regulation of prenatal embryonic development by paternal imprinted loci

The paper investigates the temporal roles of paternal imprinted loci H19-DMR and IG-DMR in prenatal embryonic development using semi-cloned embryos.

Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit

The paper uses a systems biology approach to analyze how glucocorticoid receptor sensitivity and energy deficit contribute to metabolic dysfunction in PTSD.

Long-read sequencing identified a causal structural variant in an exome-negative case and enabled preimplantation genetic diagnosis

Transcriptional Network Analysis on Brains Reveals a Potential Regulatory Role of PPP1R3F in Autism Spectrum Disorders

This study identifies PPP1R3F as a master regulator in ASDs using network deconvolution and RNA-Seq data from cerebellum samples.

N6-Methyladenine DNA Modification in Human Genome

This study identifies widespread N6-methyladenine (6mA) modification in the human genome, links it to gene expression, and shows its role in cancer by demonstrating reduced 6mA levels in tumors.

Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.

HadoopCNV: A Dynamic Programming Imputation Algorithm To Detect Copy Number Variants From Sequencing Data

HadoopCNV detects copy number variants from WGS data using dynamic programming and allelic depth, outperforming existing tools in accuracy and scalability.

A variant in TAF1 is associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features

The paper identifies a maternally inherited TAF1 variant in two brothers with severe intellectual disability and distinctive facial features, linking it to a new syndrome.