Deep brain stimulation of the mesencephalic locomotor centre induces stimulation-dependent behavioural states beyond locomotion
Martina Wilhelm, Johannes Hartig, Teresa Christina Faupel, Dongdong Sun, Saskia Marie Moritz, Jérémy Signoret-Genest, Fereschta Hakimi, Annemarie Sodmann, Felicitas Schlott, Susanne Knörr, Philip Tovote, Chi Wang Ip, Felix Fluri, Michael Klaus Schuhmann, Jens Volkmann, Robert Blum
This study investigates how different frequencies and amplitudes of DBS in the MLR affect behavior in rats, finding that high-frequency stimulation induces hyperlocomotion and defensive behaviors, while low-frequency stimulation causes immobility.
bioRxiv · Sep 24, 2026 · PreprintNeuroscience