Spatial Tumour Tissue Distribution Dynamics of a Bicycle Peptide-MMAE Toxin Conjugate Profiled by Targeted Mass Spectrometry
Maria-Konstantina Ioannidi, Simon Davis, Tianen He, Svenja Hester, Mike Rigby, Finn Holding, Phil Jeffrey, Michael J. Skynner, Iolanda Vendrell, Roman Fischer, Benedikt Mathias Kessler
This paper develops a spatial pharmacology workflow using LCM-LC-PRM to profile MMAE distribution in tumour and healthy tissues, revealing heterogeneous and time-dependent accumulation patterns.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology