Author

Fiona M. Diffin

University of Bristol

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Mark D. SzczelkuniD· 2 shared Oscar Enrique Torres MontaguthiD· 2 shared Stephen CrossiD· 2 shared Alex Hughes-GamesiD· 1 shared D. Dunn· 1 shared Kincaid W.A. Ingram· 1 shared Laura J. LeeiD· 1 shared S. McDowall· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

Mark D. SzczelkunORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Individual Staphylococcus aureus SauUSI restriction endonuclease motors fragment methylated DNA

S.J. Shaw, Alex Hughes-Games, Oscar Enrique Torres Montaguth, S. McDowall, Fiona M. Diffin, D. Dunn, Stephen Cross, Mark D. Szczelkun

This study investigates how the Staphylococcus aureus SauUSI restriction enzyme recognizes and cleaves methylated DNA through ATP-driven translocation and loop formation.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology

ENDO-Pore: High-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing

Oscar Enrique Torres Montaguth, Stephen Cross, Kincaid W.A. Ingram, Laura J. Lee, Fiona M. Diffin, Mark D. Szczelkun

ENDO-Pore maps DNA cleavage events using nanopore sequencing, with CSI identifying cleavage sites, and it was benchmarked with restriction endonucleases and CRISPR Cas12a.

Nucleic Acids Research · Aug 12, 2021Peer-reviewedMolecular Biology