Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction.
Sara M.P. Lambrichts, Laura van der Taelen, Irene Pastor, Peter J. A. Leenders, Nicole J.J.E. Bitsch, Daria Majcher, Denise J. H. P. Hermes, S P Simmonds, Marcel H. M. van Herwijnen, Rick Kamps, Ellen Weltjens, Phyllis J. J. Jessen, H.P. Steinbusch, Floor Arentz, Maximilian Wiesmann, , Sébastien Foulquier
This study shows that reduced Trpv4 and Klf2 in brain microvessels correlates with neurovascular dysfunction and cognitive decline in an HFpEF rat model.
Journal of Cerebral Blood Flow & Metabolism · Jun 12, 2026Peer-reviewedNeuroscience