Depletion of rRNA Methyltranferase METTL5 Enhances Anti-Tumor Immune Response via Neoantigen Generated from Cryptic Translation
Yangyi Zhang, Xiaoyan Shi, Yuci Wang, Ruiqi Wang, Folan Lin, Yanlan Cao, Wanqiu Li, Hao Chen
This study shows that inhibiting METTL5 increases neoantigen production and enhances anti-tumor immunity through non-canonical translation in murine models.
bioRxiv · Jun 6, 2025 · PreprintCancer Biology