Cryo-EM of a Divergent Herpesvirus Reveals Structural Conservation and Novelty Including a Portal-Vertex Tegument Protein with Multiple Macrodomain-like Folds
Amit Meir, Filip Petrov, Marion J. McElwee, James Streetley, Liisa Holm, Joe Grove, Andrew J. Davison, Frazer J. Rixon, David Bhella
The paper uses cryo-EM to determine the structure of Ictalurid herpesvirus 1, revealing conserved and novel features including a portal-vertex tegument protein with multiple macrodomain-like folds.
bioRxiv · Feb 13, 2026 · PreprintMicrobiology