AI-guided design of common light chains to enable manufacturable bispecific antibodies
Longfei Cong, Brian M Richardson, Yi Zhou, Tong Li, Roger Shek, Yuxiang Lang, Ziwei Pang, Freddy Garces, Jarrod B. French, Per Jr Greisen
This paper presents an AI framework to design common light chains for bispecific antibodies, reducing experimental screening and enabling production-ready antibodies for 7 out of 10 targets.
bioRxiv · Oct 11, 2025 · PreprintBioengineering