Author

Longfei Cong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Per Jr GreiseniD· 3 shared Roger ShekiD· 3 shared Trang Nguyen· 2 shared Yi LiiD· 2 shared Yifan LiiD· 2 shared Yuxiang Lang· 2 shared Brian M Richardson· 1 shared Chenrui XuiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioengineering

Per Jr GreisenORCID

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3 papers

Recent·Most cited

De Novo Computational Design of VHH Nanobodies Against LGR5

Chenrui Xu, Yifan Li, Trang Nguyen, Yi Zhou, Longfei Cong, Tek-Hyung Lee, Yuxiang Lang, Roger Shek, Yi Li, Per Jr Greisen

This paper presents a computational pipeline for designing VHH nanobodies against LGR5 without structural templates, resulting in high-affinity, stable binders validated by cryo-EM.

bioRxiv · Dec 5, 2025 · PreprintBioengineering

AI-guided design of common light chains to enable manufacturable bispecific antibodies

Longfei Cong, Brian M Richardson, Yi Zhou, Tong Li, Roger Shek, Yuxiang Lang, Ziwei Pang, Freddy Garces, Jarrod B. French, Per Jr Greisen

This paper presents an AI framework to design common light chains for bispecific antibodies, reducing experimental screening and enabling production-ready antibodies for 7 out of 10 targets.

bioRxiv · Oct 11, 2025 · PreprintBioengineering

Computational Design of Soluble CCR8 Analogues with Preserved Antibody Binding

Trang Nguyen, Songming Liu, Yifan Li, Longfei Cong, Roger Shek, Tek Hyung Lee, Yi Li, Per Jr Greisen

This paper computationally designs soluble CCR8 analogues that retain native antibody binding, achieving a 62% success rate with preserved structural and functional properties.

bioRxiv · Aug 18, 2025 · PreprintBioengineering