Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses
F. Vecchio, A. Carre, D. Korenkov, Z. Zhou, P. Apaolaza, S. Tuomela, O. Burgos-Morales, I. Snowhite, J. Perez-Hernandez, B. Brandao, G. Afonso, C. Halliez, J. Kaddis, S. C. Kent, M. Nakayama, , R. Mallone
This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.
bioRxiv · Aug 19, 2023 · PreprintImmunology