Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
G. Babolmorad, A. Latif, N. M. Pollock, I. K. Domingo, C. Delyea, A. M. Rieger, W. T. Allison, A. P. Bhavsar
This paper shows platinum and cisplatin activate TLR4, contributing to ototoxicity, and identifies TLR4 as a target to mitigate cisplatin-induced hearing loss.
The EMBO Reports · Mar 18, 2021Peer-reviewedPharmacology & Toxicology