Identification of topoisomerase as a precision-medicine target in chromatin reader SP140-driven Crohns disease
H. Amatullah, S. Digumarthi, I. Fraschilla, F. Adiliaghdam, G. Bonilla, L. P. Wong, R. Sadreyev, K. L. Jeffrey
This study identifies SP140 as a repressor of topoisomerases in immune diseases and shows TOP inhibition can reverse SP140-driven pathology.
bioRxiv · Sep 20, 2021 · PreprintImmunology