Author

K. L. Jeffrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:metagenomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:mouse· 1

Frequent Co-Authors

F. Adiliaghdam· 2 shared H. Amatullah· 2 shared L. P. Wong· 2 shared R. Sadreyev· 2 shared S. Digumarthi· 2 shared D. Kadosh-Kariti· 1 shared G. Bonilla· 1 shared H. Hajjo· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

F. Adiliaghdam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

S. Carasso, R. Zaatry, H. Hajjo, D. Kadosh-Kariti, N. Ben-Assa, R. Naddaf, N. Mandelbaum, S. Pressman, Y. Chowers, T. Gefen, K. L. Jeffrey, J. Jofre, M. J. Coyne, L. E. Comstock, I. Sharon, N. Geva-Zatorsky

The paper identifies DNA inversion states in the gut microbiota linked to inflammation and bacteriophages, showing their impact on bacterial function and immune response.

bioRxiv · Mar 31, 2023Microbiology

Human enteric viruses shape disease phenotype through divergent innate immunomodulation

F. Adiliaghdam, H. Amatullah, S. Digumarthi, T. L. Saunders, R.-U. Rahman, L. P. Wong, R. Sadreyev, L. Droit, J. Paquette, P. Goyette, J. Rioux, R. Hodin, K. Mihindukulasuriya, S. A. Handley, K. L. Jeffrey

The paper shows that human viromes from healthy and IBD patients differentially modulate innate immunity, influencing disease phenotypes through nucleic acid sensing.

bioRxiv · Oct 14, 2021 · PreprintImmunology

Identification of topoisomerase as a precision-medicine target in chromatin reader SP140-driven Crohns disease

H. Amatullah, S. Digumarthi, I. Fraschilla, F. Adiliaghdam, G. Bonilla, L. P. Wong, R. Sadreyev, K. L. Jeffrey

This study identifies SP140 as a repressor of topoisomerases in immune diseases and shows TOP inhibition can reverse SP140-driven pathology.

bioRxiv · Sep 20, 2021 · PreprintImmunology