Trypanosoma brucei ultra-structure cell modifications caused by knockdown of the ribonuclease Rrp44/Dis3
G. Cesaro, P. M. Hiraiwa, F. R. G. Carneiro, V. Rouam, P. Legrand, J. J. Conesa, M. Refregiers, E. Pereiro, B. G. Guimaraes, F. Jamme, N. I. T. Zanchin
This study shows that TbRRP44 depletion in Trypanosoma brucei causes vacuole expansion, nuclear enlargement, mitochondrial inactivation, and autophagy, leading to cell death.
bioRxiv · Feb 29, 2020 · PreprintCell Biology