The impact of phenotypic heterogeneity of tumour cells on treatment and relapse dynamics
M. Raatz, S. Shah, G. Chitadze, M. Brüggemann, A. Traulsen
This paper models how phenotypic heterogeneity in cancer cells affects treatment outcomes and relapse, showing that growth rate-dependent therapies delay relapse but may create resistant subpopulations.
bioRxiv · Nov 27, 2020Evolutionary Biology