ImmunologybioRxivPreprint
Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity
Y. Zhang, R. Morris, A. M. D. Lorenzo…·J. I. Ellyard
The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.