Y. Zhang

A shared wireless acquisition core for cortical and peripheral recordings in freely moving mice

This paper introduces a wireless headstage for simultaneous cortical, muscle, and movement recordings in freely moving mice, demonstrating its utility in seizure detection and behavior-related neural activity analysis.

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

Single-atom inhibition of oncogenic drivers through cysteine coordination

This paper introduces single-atom inhibition using gold to target oncogenic proteins by coordinating with cysteine residues, showing efficacy in suppressing cancer cell growth and tumor progression.

Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

Vascular transcriptional and metabolic changes precede progressive intra-renal microvascular rarefaction in autosomal dominant polycystic kidney disease

This study identifies early vascular transcriptional and metabolic changes preceding microvascular rarefaction in ADPKD using mouse models and human cohorts.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Rhesus Infant Nervous Temperament Predicts Peri-Adolescent Central Amygdala Metabolism & Behavioral Inhibition Measured by a Machine-Learning Approach

The paper uses machine learning to link infant rhesus monkey temperament with peri-adolescent brain metabolism and defensive behavior.

Comparative transcriptomic and lipidomic analysis of fatty acid accumulation in three Camellia oleifera varieties during maturation

This study compares transcriptomic and lipidomic profiles of three Camellia oleifera varieties during seed maturation, linking fatty acid composition to gene expression patterns.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

FACS-Sortable Triple Emulsion Picoreactors for Screening Reactions in Biphasic Environments

This paper develops FACS-sortable triple emulsion picoreactors for high-throughput screening of biphasic reactions, demonstrating stability and compatibility with protein synthesis.

The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

This study shows the gut microbiome enhances metabolite cycling in Drosophila, interacting with the circadian clock and diet, with high-protein diets increasing cycling and high-sugar diets suppressing it.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

A Fluorogenic Green Merocyanine-Based Probe to Detect Heparanase-1 Activity

This paper designs and synthesizes a fluorogenic green probe to detect HPSE-1 activity, showing a 278-fold fluorescence turn-on response in the presence of recombinant human HPSE-1.

Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor

This paper describes a method to generate high-purity, scalable human iPSC-derived cardiomyocytes using a bioreactor, showing improved viability, function, and consistency compared to traditional methods.

SHOOTMERISTEMLESS autoactivation: A prerequisite for fruit metamorphosis

The paper shows that CrSTM autoactivation through a cis regulatory element is essential for Capsella fruit shape transition during metamorphosis.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Identification of SEC61B as a novel regulator of calcium flux and platelet hyperreactivity in diabetes mellitus

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

Ovarian disrupting effects and mechanisms of long- and short-chain per- and polyfluoroalkyl substances in mice

This study investigates the effects of long- and short-chain PFAS on ovarian function in mice, finding that long-chain PFAS disrupt follicle maturation and ovulation via PPARγ activation.

PathEX: Make Good Choice for Whole Slide Image Extraction

PathEX improves tile image extraction from whole slide images by adjusting IoT and BoT parameters to focus on annotated regions' boundaries and exclude blank tiles.

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

This study uses a Transformer model to design novel succinate dehydrogenase inhibitors against agricultural fungi, resulting in potent antifungal compounds through virtual screening and optimization.

Robust Neutralization of SARS-CoV-2 Variants Including JN.1 and BA.2.87.1 by Trivalent XBB Vaccine-Induced Antibodies

The paper compares antibody responses from individuals with XBB reinfection and those vaccinated with WSK-V102C, showing the vaccine induces stronger neutralization against SARS-CoV-2 variants including JN.1 and BA.2.87.1.

Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression

This study shows that PLK1-mediated PDHA1 phosphorylation impairs mitochondrial function and promotes Cr(VI)-induced lung cancer progression by disrupting energy metabolism and apoptosis.