Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane penetrating loop
F. Hoelzgen, R. Zalk, R. Alcalay, S. Cohen Schwartz, G. Garau, A. Shahar, O. Mazor, G. A. Frank
This study determines the cryo-EM structure of anthrax toxin's protective antigen complexed with an antibody, revealing how the antibody neutralizes the toxin by preventing pore formation.
bioRxiv · Apr 18, 2021Biochemistry