The iron maiden. Cytosolic aconitase/IRP1 conformational transition in the regulation of ferritin translation and iron hemostasis
C. Hognon, E. Bignon, G. Harle, N. Touche, S. Grandemange, A. Monari
This study uses molecular dynamics simulations to analyze how the iron-sulfur cluster influences the conformational transition of aconitase/IRP1 and its interaction with mRNA, impacting ferritin translation and iron homeostasis.
bioRxiv · Jul 28, 2021Biophysics