Hormonal steroids bind the Neisseria gonorrhoeae multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor
G. Hooks, J. Ayala, G. Beggs, J. R. Perfect, M. Schumacher, W. M. Shafer, R. G. Brennan
This study identifies hormonal steroids that bind MtrR, a regulator in Neisseria gonorrhoeae, leading to reduced DNA binding and activation of multidrug efflux pumps and stress-response mechanisms.
bioRxiv · Jun 13, 2023 · PreprintBiochemistry