Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability
A. Franchitto, V. Marabitti, G. Lillo, E. Malacaria, V. Palermo, P. Pichierri
The paper shows WRNIP1 stabilizes genome integrity by mediating ATM-dependent CHK1 phosphorylation and RAD51 ssDNA association in response to R-loop accumulation.
bioRxiv · Nov 29, 2019 · PreprintCancer Biology