Author

V. Palermo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:DNA methylation· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Franchitto· 4 shared P. Pichierri· 4 shared E. Malacaria· 2 shared M. Semproni· 2 shared P. Valenzisi· 2 shared V. Marabitti· 2 shared A. Noto· 1 shared A. Pellicioli· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCell Biology

A. Franchitto

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Author profile →

4 papers

Recent·Most cited

Switch-Like Phosphorylation of WRN Integrates End-Resection with RAD51 Metabolism at Collapsed Replication Forks

V. Palermo, E. Malacaria, M. Semproni, B. Perdichizzi, P. Valenzisi, M. Sanchez, F. Marini, A. Pellicioli, A. Franchitto, P. Pichierri

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

bioRxiv · Feb 11, 2024Cell Biology

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

A. Noto, P. Valenzisi, F. Fratini, T. Kulikowicz, J. A. Sommers, F. Di Feo, V. Palermo, M. Semproni, M. Crescenzi, R. M. Brosh, A. Franchitto, P. Pichierri

This study shows that phosphorylation-dependent WRN-RPA interaction is essential for replication fork recovery after stalling at secondary DNA structures, preventing DNA damage and G4 accumulation.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability

A. Franchitto, V. Marabitti, G. Lillo, E. Malacaria, V. Palermo, P. Pichierri

The paper shows WRNIP1 stabilizes genome integrity by mediating ATM-dependent CHK1 phosphorylation and RAD51 ssDNA association in response to R-loop accumulation.

bioRxiv · Nov 29, 2019 · PreprintCancer Biology

Generation of inducible SMARCAL1 knock-down iPSC to model severe Schimke immune-osseous dysplasia reveals a link between replication stress and altered expression of master differentiation genes

G. M. Pugliese, F. Salaris, V. Palermo, V. Marabitti, N. Morina, A. Rosa, A. Franchitto, P. Pichierri

This study generates SMARCAL1 knock-down iPSCs to model Schimke immune-osseous dysplasia, revealing replication stress and altered gene expression as key factors in disease pathogenesis.

bioRxiv · Feb 10, 2019Cell Biology