The kinase inhibitor AT9283 selectively kills colorectal cancer cells with hyperactive NRF2
L. Torrente, G. Maan, L. Casares, A. Jackson, T. Honda, G. Wells, E. Kulesskiy, J. Saarela, A. T. Dinkova-Kostova, L. de la Vega
The paper identifies AT9283 as a drug that selectively kills colorectal cancer cells with hyperactive NRF2, showing its potential as a therapeutic target.
bioRxiv · Oct 21, 2019 · PreprintCancer Biology