Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei
A. Alghamdi, J. C. Munday, G. D. Campagnaro, D. Gurvic, F. Svensson, C. E. Okpara, A. Kumar, M. E. Martin Abril, P. Mili?, L. Watson, D. Paape, L. Settimo, A. Dimitriou, J. Wielinska, G. Smart, , H. P. De Koning
The paper identifies mutations in TbAQP2 that enable pentamidine permeation, showing how specific structural changes in the aquaporin pore allow drug entry in Trypanosoma brucei.
bioRxiv · Mar 8, 2020Biochemistry