A. Kumar

Genetic diversity and population structure of Ethiopian taro Colocasia esculenta (L.) Schott) as revealed by SSR markers

This study assesses genetic diversity and population structure of Ethiopian taro using SSR markers, finding low diversity at individual loci but high multilocus genotypic diversity and weak genetic differentiation among populations.

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

This study elucidates the molecular mechanism of redox-coupled sodium pumping in the Rnf complex using cryo-EM, biochemical assays, and simulations.

Evaluating the Anti-tumor efficacy and safety of AEV01 in Glioma and Hepatocellular Carcinoma: An In Vitro and In Vivo approach.

This study evaluates the anti-tumor efficacy and safety of AEV01 in glioma and hepatocellular carcinoma using in vitro and in vivo models, finding dose-dependent cytotoxicity and reduced tumor markers with no significant organ toxicity.

Unraveling Structural Disparities in Human and Mycobacterium Tuberculosis Type-I Fatty Acid Synthase

This study compares the structural differences between human and Mycobacterium tuberculosis type-I fatty acid synthase using molecular dynamics simulations to identify potential drug targets.

Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans

This study shows that heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide extend C. elegans lifespan by improving proteostasis and immune responses through modulation of insulin-like signaling, autophagy-lysosome pathway, and antioxidant defenses.

Dynamic control of neural manifolds

This paper investigates how neural trajectories and their subspaces are dynamically controlled in the central nervous system through mechanisms like gain modulation and clustered inhibition.

The Soybean Cyst Nematode Effector Cysteine Protease 1 (CPR1) Targets a Mitochondrial Soybean Branched-Chain Amino Acid Aminotransferase (GmBCAT1) for Degradation

This study identifies CPR1, a conserved soybean cyst nematode effector protease, which targets GmBCAT1 for degradation, enhancing nematode susceptibility.

Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

The paper measures the mechanical properties of NompC gating springs and finds nonlinear compliance that may regulate mechanotransduction sensitivity.

Multispectral live-cell imaging with uncompromised spatiotemporal resolution

The paper introduces a multispectral imaging approach for live-cell imaging, enabling accurate unmixing of low signal-to-noise ratio data at video rates.

Single-nucleus transcriptomic analysis reveals the regulatory circuitry of myofiber XBP1 during regenerative myogenesis

This study shows that XBP1 in myofibers regulates muscle regeneration through cell-autonomous and non-autonomous mechanisms by affecting satellite cells and non-myogenic cells.

Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain

This study investigates the role of the autophagy-lysosomal pathway in Huntington's disease, finding that autophagic flux declines due to substrate clearance deficits in later stages.

Lipidomics and colistin resistance in non-human isolates of Acinetobacter seifertii

This study identifies four colistin-resistant Acinetobacter seifertii strains from tank milk, revealing lipidomic differences and potential resistance mechanisms not seen in A. baumannii.

Use of Stem Cell-Derived Cardiomyocyte and Nasal Epithelium Models to Establish a Multi-Tissue Model Platform to Validate Repurposed Drugs Against SARS-CoV-2 Infection

The paper validates repurposed drugs against SARS-CoV-2 using stem cell-derived cardiomyocyte and nasal epithelium models, confirming fluvoxamine's antiviral efficacy in combination with other drugs.

Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

MicroRNA hsa-miR-203a-3p promotes H1N1 and NDV Virus Replication by suppressing the IFNA signaling.

This study identifies miR-203a-3p as a pro-viral microRNA that suppresses type-I interferon signaling to promote H1N1 and NDV replication.

Probing the Molecular Interactions of A22 with Prokaryotic Actin MreB and Eukaryotic Actin: A Computational and Experimental Study

This study investigates A22's interactions with prokaryotic MreB and eukaryotic actin using computational and experimental methods, revealing strong binding and toxicity to eukaryotic cells.

Real-time visualization reveals Mycobacterium tuberculosis ESAT-6 disrupts phagosome via fibril-mediated vesiculation

This study reveals how ESAT-6 disrupts the phagosomal membrane through fibril-mediated vesiculation, leading to host cell death and promoting Mtb infection.

Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics

This paper designs a multi-epitope tolerogenic vaccine targeting CYP2D6 for autoimmune hepatitis using immuno-informatics, showing it induces IL-10 and programs dendritic cells toward a tolerogenic state.

Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins

This paper develops a broad-spectrum multiepitope vaccine for bluetongue virus targeting conserved T cell epitopes in structural proteins, showing strong binding and potential for inducing immune responses.

p53 mediated regulation of LINE1 retrotransposon derived R-loops

This study shows p53 suppresses L1 retrotransposon-derived R-loops by recruiting repressive epigenetic marks and inhibiting activating marks, preventing DNA damage and inflammation.

Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma

This study shows that peroxidasin (PXDN) promotes invasion in metastatic melanoma by supporting a mesenchymal-like transcriptional phenotype, as demonstrated through transcriptomic and proteomic analyses.

Elucidating role of long non-coding RNAs of Tamarindus indica Linn. in post-transcriptional gene regulation.

This study predicts and validates 320 lncRNAs in tamarind, analyzing their roles in gene regulation and biological pathways.

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

This study shows that 2-oxoglutarate induces dodecamer assembly of Methanosarcina mazei glutamine synthetase, enhancing its activity through a cooperative mechanism.

Inhibition of Proteasome Activity Facilitates Definitive Endodermal Specification of pluripotent Stem Cells by influencing YAP signaling

This study shows that inhibiting proteasome activity enhances definitive endodermal specification in pluripotent stem cells through YAP signaling.

Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

Cathepsin B regulates ovarian reserve quality and quantity via mitophagy by modulating IGF1R turnover.

This study identifies Cathepsin B's role in regulating ovarian reserve through mitophagy and IGF1R turnover, showing its conservation in higher vertebrates.

A Spatial Prioritization of Conifer Management to Defend and Grow Sagebrush Cores

This paper develops a spatial prioritization framework for conifer management to improve sagebrush ecological integrity by targeting high-priority areas for treatment.

Carbon nanoparticle exposure strengthens water-relation parameters by stimulating abscisic acid pathway and aquaporins genes in rice

This study shows carbon nanoparticles improve rice growth and water use efficiency by enhancing the ABA pathway and aquaporin gene expression, leading to better stress tolerance.

PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.