A basic leucine zipper uses a dimer pathway to locate its targets in DNA mixtures
Mikhail L. Kuravsky, Gabriel Grey, Conor Kelly, Polenus D Sarkar, Jeremie Gaudez, Sarah L. Shammas
This study shows that CREB basic zippers preferentially search DNA targets as dimers rather than monomers, with dimeric complexes being more efficient in binding DNA.
bioRxiv · Aug 25, 2025 · PreprintBiophysics