Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex
Matthew E. R. Maitland, Gabriel Onea, Dominic D. G. Owens, Brianna C. Gonga‐Cavé, Xu Wang, C.H. Arrowsmith, Dalia Baršytė-Lovejoy, Gilles Lajoie, Caroline Schild‐Poulter
The paper shows that the CTLH E3 ligase complex regulates substrate selectivity and autoregulation by exchanging its β-propeller subunits WDR26 and muskelin.
bioRxiv · Mar 8, 2024 · PreprintMolecular Biology