Biosynthesis of 14-membered cyclopeptide alkaloids via non-heme-iron- and 2-oxoglutarate-dependent oxidative decarboxylation
Jordan A. Hungerford, Lisa S. Mydy, Xiaofeng Wang, Lorena Mendoza-Perez, Derrick A Ousley, Khadija Shafiq, Kali M McDonough, Wenjie Li, Gabrielle May, Desnor N. Chigumba, Shengrui Yao, Roland D. Kersten
This study identifies the biosynthetic pathway for a 14-membered cyclopeptide alkaloid, lotusine A, involving non-heme-iron and 2-oxoglutarate-dependent oxidative decarboxylation and SAM-dependent N-terminal methylation.
Journal of the American Chemical Society · Feb 16, 2026Peer-reviewedBiochemistry