synaptic & neural circuits

PhyMorphS: A Physics-Guided Framework for Mesh-Based Morphological Synthesis of White Matter Microstructures

PhyMorphS generates realistic white matter microstructures using physics-guided mesh growth, reproducing key morphological features and enabling dMRI signal studies.

The Where and When of Tracking Sound Sources Head-based auditory motion tracking integrates velocity and spatial error within a common delayed frame

This study investigates how the auditory system tracks moving sound sources by integrating velocity and spatial error in a delayed frame, showing improved prediction with preceding head orientation.

Parsimonious Creatures: Building Gene Regulatory Networks Robust to Somatic Evolution

This study designs gene regulatory networks to slow somatic evolution in simplified multicellular organisms and identifies tradeoffs between network robustness and fitness.

NeuroDisco: Interfacing neuronal populations - cell by cell, millisecond by millisecond, day by day

NeuroDisco provides optogenetic stimulation to neuronal cultures to reduce synchronized bursting and enable functional analysis of neuronal activity.

Multiplexed mapping of long-range projections with FluoCode, a combinatorial fluorescent barcoding system

The paper introduces FluoCode, a fluorescent barcoding system for multiplexed projection mapping in mice and marmosets, revealing fine-scale topographic maps in subcortical regions.

Open-BEATBox: an open-source autonomous operant chamber for high-throughput data acquisition of complex behaviour

Open-BEATBox enables continuous, autonomous assessment of complex mouse behavior, generating more trials and reducing experimenter workload without adverse effects.

Replicable Connectivity and Spectral Alterations of Functional Networks in Major Depression

This study identifies consistent connectivity, spectral, and spatial changes in intrinsic brain networks in major depression across independent cohorts.

Pre-synaptic facilitation of corticospinal output improves dexterity and finemotor control after stroke

This study uses deep brain stimulation to enhance corticospinal output in monkeys with CST lesions, improving arm and hand function and fine motor control.

Mapping and longitudinal imaging of potentiated synapses in the mouse hippocampus using SynActive-eGRASP

The paper develops SA-eGRASP to map and track potentiated synapses in the mouse hippocampus following learning and uses it to study long-term synaptic dynamics.

Regulation of sociality and neuronal development by the translation initiation factor eIF4H1 in Drosophila

This study identifies eIF4H1 as a conserved gene regulating sociality and neuronal development in Drosophila, supporting a genetic toolkit for social traits across species.

Electrophysiological Dynamics of Default Network Suppression

The paper investigates network competition in the brain using electrophysiology and neuroimaging, finding temporally layered antagonism between default and task-related networks, with distinct patterns in the hippocampus.

Distinguishing evidence accumulation from choice confidence in neural signatures of perceptual decision making

This study investigates whether the centro-parietal positivity (CPP) reflects evidence accumulation or subjective confidence during perceptual decision-making, finding that CPP is an evidence accumulation signal, not confidence.

Projection-specific filtering of delta-theta input by layer 5 neurons in mouse secondary visual cortex

The paper investigates how two types of layer 5 neurons in mouse secondary visual cortex process delta-theta rhythmic input, finding differences in filtering but not in spike timing once firing.

Quantifying Excitation-Inhibition Harmony and Its Breakdown during Epileptogenesis in a Spiking Neural Network of the Hippocampal CA1

This paper quantifies excitation-inhibition balance in a spiking neural network model of hippocampal CA1, showing how disruptions in this balance lead to epileptogenic state transitions.

Feasible closed-loop stimulation for neural latent dynamics control

This study uses simulations to show that low-dimensional optogenetic stimulation can effectively control neural latent dynamics with fewer channels than neurons, guiding future hardware design.

Broad Cognitive and Motivational Enhancement through M4-Selective Muscarinic Modulation

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

Developmental interactions between oscillatory and spontaneous neural activity support improvements in inhibitory control from adolescence into adulthood

This study examines how developmental changes in oscillatory and spontaneous neural activity support improved inhibitory control from adolescence to adulthood using EEG data.

Individual differences reveal shared computational structure in perceptual decision-making

The paper uses population-level individual differences to discover shared computational components in perceptual decision-making, revealing a six-dimensional structure across datasets.

Increased Cognitive Load Expands, Stabilizes, and Aligns Visual Representation Across the Human Brain

This study shows that increased cognitive load expands and stabilizes visual representations across the brain, enhances cross-regional coordination, and reduces neural variability.

Phase-locked dual-band vibration bursts strengthen anti-kindling by vibrotactile coordinated reset stimulation in a spiking network model

The paper shows that a dual-band vibration burst improves anti-kindling in a spiking network model compared to single-frequency stimulation.

Generalizable sex differences in functional brain organization follow the cortical hierarchy in youth

The paper examines sex differences in functional brain connectivity across youth, finding that males show greater network integration while females show greater network segregation along the sensorimotor-association axis.

Reinforcement sculpts synaptic ensembles for operant dendritic control

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

Circuit and cell-type mechanisms of the spectrolaminar motif of cortical oscillations

The paper uses a bio-realistic model of mouse primary visual cortex to show that cortical oscillations follow a spectrolaminar motif, with gamma in superficial layers and alpha/beta in deep layers, driven by specific cell types and synaptic properties.

Cross-excitation in dorsal root ganglia redistributes coding capacity from stimulus intensity to stimulus location

The paper models cross-excitation in dorsal root ganglia to show it improves spatial localization at the cost of intensity encoding, leveraging the Weber-Fechner law.

Curved geometry shapes the observability of hippocampal oscillations

The paper shows curved hippocampal geometry masks theta oscillations through regional cancellation, while beta and gamma oscillations remain observable due to less coordinated generators.

Active eye modeling: a tool for estimating retinal image quality across the visual field in everyday life

This paper introduces active eye modeling to estimate retinal image quality across the visual field during everyday activities, finding that near work under dim lighting increases peripheral blur.

Compositional computations in the primate frontal cortex

The paper investigates how neural circuits in the primate frontal cortex support compositional generalization by separating computations into spatial and temporal components and identifying biases when these components are misaligned.

Next generation Human Neocortical Neurosolver model with biophysically realistic somatic, dendritic and synaptic dynamics

The paper updates the Human Neocortical Neurosolver model to include biophysically realistic dynamics in human neurons, enabling better interpretation of EEG/MEG signals.

Dopamine synthesis capacity and tau pathology differentially modulate rest-to-task functional network dynamics

This study examines how dopamine synthesis and tau pathology affect functional brain network dynamics during rest and task performance in young and older adults.

An open-access neuroimaging-compatible virtual town task for assessing human spatial navigation

The paper introduces an open-access virtual navigation task compatible with neuroimaging, demonstrating its use with EEG and behavioral tracking in human participants.