Liver Kinome Profiling Identifies PS1145 as a Potential Therapeutic molecule for amelioration of Systemic Inflammation in Alcohol-related Liver Disease
Manisha Yadav, Abhishak Gupta, Sanju Yadav, Vipul Sharma, Yash Magar, Deepanshu Deepanshu, Tahseen Khan, Neha Sharma, Kavita Yadav, Nupur Sharma, Vasundhra Bindal, Sushmita Pandey, Gaurav Tripathi, Rimsha Saif, Babu Mathew, , Jaswinder Singh Maras
The paper identifies PS1145 as a potential therapeutic for reducing systemic inflammation in alcohol-related liver disease by inhibiting IKK phosphorylation and TLR dimerization.
bioRxiv · Jul 2, 2025 · PreprintPharmacology & Toxicology