Mutant ATXN1 impacts human and mouse microglia and contributes to cognitive, mood, and motor deficits in SCA1 mice
Adem Selimovic, Gourango Talukdar, Gavin J. Fuchs, Vamika Sharma, Khadija N Abbas, Sriyan C Reddy, Eshaan Parnerkar, Ian M. Brooks, Ying Zhang, Michael D. Koob, Yasushi Nakagawa, Harry T. Orr, Marija Cvetanović
This study shows that mutant ATXN1 affects microglia in human and mouse models, leading to cognitive, mood, and motor deficits in SCA1 mice, which are ameliorated by reducing mutant ATXN1 in microglia.
bioRxiv · Feb 17, 2026 · PreprintNeuroscience