Author

Gerard Duncan

Frederick National Laboratory for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:fine-mapping· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Þorkell AndréssoniD· 3 shared Aidan O’BrieniD· 1 shared Alexandra M. ThornockiD· 1 shared Alison P. KleiniD· 1 shared Amit K. BeheraiD· 1 shared Arun Prasath DamodaraniD· 1 shared Bandana KumariiD· 1 shared Brian Matthew WolpiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersGenetics

Þorkell AndréssonORCID

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3 papers

Recent·Most cited

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as modulating risk for melanoma and nevi via RAS activation

Rohit Thakur, Mai Xu, Alexandra M. Thornock, Joshuah Yon, Samuel Anyaso-Samuel, Martin Lauss, Thomas Rehling, Linh T. Bui, Hayley Sowards, Gerard Duncan, Lea Jessop, Timothy Myers, Raj Chari, Erping Long, Karen M. Funderburk, , Kevin M. Brown

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

bioRxiv · Feb 9, 2026 · PreprintGenetics

RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria

Amit K. Behera, Jeongjin J. Kim, Shreya Kordale, Filip Pekovic, Arun Prasath Damodaran, Bandana Kumari, Sandra Vidak, Ethan Dickson, Mei‐Sheng Xiao, Gerard Duncan, Þorkell Andrésson, Tom Misteli, Eugene Valkov, Thomas Gonatopoulos-Pournatzis

The paper introduces CRASP-Seq, a method to identify gene regulators of alternative splicing, and finds ZNF207 regulates LMNA splicing in progeria by interacting with U1 snRNP.

Molecular Cell · Dec 30, 2025Peer-reviewedGenetics

Allelic effects on KLHL17 expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

Katelyn E. Connelly, Katherine Hullin, Ehssan Abdolalizadeh, Jun Zhong, Daina Eiser, Aidan O’Brien, Irene J. Collins, Sudipto Das, Gerard Duncan, Stephen Jacob Chanock, Rachael Z. Stolzenberg‐Solomon, Alison P. Klein, Brian Matthew Wolpin, Jason W. Hoskins, Þorkell Andrésson, , Laufey Thora Amundadottir

The paper fine-maps a PDAC GWAS signal at chr1p36.33 and identifies KLHL17 as a target gene regulated by JunB/D, with potential implications for inflammation and PDAC risk.

medRxiv · Sep 16, 2024 · PreprintGenetic & Genomic Medicine