Genome-resolved ecology and evolution of the microbiome enabled by quantitative long-read metagenomics
M. Omar Din, Caitriona Brennan, Jianshu Zhao, Renee E. Oles, Lucas Patel, Amanda Birmingham, Dilara M. Sevilir, Lauren Hansen, Gillian M. Wright, Madison Ambre, Meika Tomita, Tara Boyer, Antonio Gonzalez, Gail L. Ackermann, Daniel McDonald, , Rob D. Knight
This paper introduces LRQ, a long-read metagenomics method that enables absolute strain abundance measurement and resolves microbial evolution in a Crohn's disease patient over eight years.
bioRxiv · Sep 29, 2026 · PreprintMicrobiology