The obesity associated BDNF intron-3 cis-regulatory element, BE5.1, modulates the effects of early-life stress on weight gain, anxiety and gene expression in a sex dependent manner.
Andrew R. McEwan, Joseph Morgan, Greg Hutchings, Alexander Rattray, Elaina Collie-Duguid, Jude Al-Jishi, Zeynab Heidari, Grace Ritchie, Louie N. van de Lagemaat, Chris Murgatroyd, Alasdair MacKenzie
The paper investigates how the BDNF intron-3 cis-regulatory element BE5.1 influences the effects of early-life stress on weight gain, anxiety, and gene expression, showing sex-dependent differences.
bioRxiv · Sep 14, 2026 · PreprintMolecular Biology