Spatial Patterning of Otic Vesicles in Human Inner Ear Organoids
Ana Garcia-Urbano, Jie Yang, David J. Pearton, M T Ahmad, Graham D. Cocks, Alexandre P Thiery, Tonglin Zheng, Andrea Streit
The paper assesses axial patterning in human inner ear organoids and finds incomplete and disorganized regionalisation, suggesting limitations in self-organization and potential strategies to enhance cell complexity in vitro.
bioRxiv · Jul 21, 2026 · PreprintDevelopmental Biology