High-throughput genetic interaction analysis in Mycobacterium tuberculosis identifies highly synergistic drug targets
Cassandra L. Chapman, XinYue Wang, Cara R Adolph, Peter C. Fineran, Greg Cook, Simon A. Jackson, Matthew McNeil
This study uses CRISPRi screening in Mycobacterium tuberculosis to identify synergistic drug targets, finding that genetic interactions predict drug-drug synergies and identifying Pks13 as a key synergistic generalist.
bioRxiv · Oct 15, 2026 · PreprintMicrobiology