Author
University of AucklandORCID 0000-0002-4512-3093Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Cassandra L. Chapman, XinYue Wang, Cara R Adolph…·Matthew McNeil
This study uses CRISPRi screening in Mycobacterium tuberculosis to identify synergistic drug targets, finding that genetic interactions predict drug-drug synergies and identifying Pks13 as a key synergistic generalist.
Ryan T. Bell, Thomas Gaudin, Yi Wu…·Eugene V. Koonin
The paper identifies YprA family helicases as a missing link connecting DISARM and Druantia immune systems in prokaryotes, revealing new defense classes and their antiviral mechanisms.
XinYue Wang, William J Jowsey, Chen‐Yi Cheung…·Matthew B. McNeil
The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.
Leighton J. Payne, Tom C. D. Hughes, Peter C. Fineran, Simon A. Jackson
The paper identifies new antiviral defence systems in prokaryotes by analyzing genetic embedding of uncharacterized genes within known defence systems.
Haidai Hu, Thomas C.D. Hughes, Philipp F. Popp…·Nicholas M. I. Taylor
This study reveals the structure and mechanism of the Zorya anti-phage defense system using cryo-EM and functional assays, showing how it detects phage invasion and activates defense.