Blocking toxin function and modulating the gut microbiota: caffeic acid phenethyl ester as a potential treatment for Clostridioides difficile infection
Yan Guo, Yong Zhang, Guizhen Wang, Hongtao Liu, Jianfeng Wang, Xuming Deng, Liuqin He, Jiazhang Qiu
This study identifies caffeic acid phenethyl ester (CAPE) as an inhibitor of TcdB, a key toxin in Clostridioides difficile infection, showing reduced pathology and microbiota modulation in mice.
bioRxiv · Aug 19, 2024 · PreprintMicrobiology