A circRNA-derived IRES-like element enables programmable translational activation of the endogenous chaperone HSP90
Guy Aoun, Andrea Vandelli, Riccardo Delli Ponti, Stefano Gustincich, Elías Bechara, Laura Broglia, Gian Gaetano Tartaglia
The paper describes a synthetic circRNA-derived IRES-like element, SynFarsa, that enhances translation of an endogenous protein, HSP90, in trans by targeting its 3'UTR.
bioRxiv · Oct 6, 2026 · PreprintBiochemistry