Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12
Paige M. Lemen, Yanning Zuo, Alexander Samir Hatoum, Price E. Dickson, Guy Mittleman, Arpana Agrawal A, Benjamin C. Reiner, Wade H. Berrettini, David George Ashbrook, Mustafa Hakan Gunturkun, Xusheng Wang, Megan K. Mulligan, Caleb J. Browne, Eric J. Nestler, Francesca Telese, , Hao Chen
This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.
eLife · Jul 29, 2026Peer-reviewedGenetics