Amyloid plaques drive state-dependent long-range circuit reorganization in the hippocampus
Zhuoyang Zhao, Joseph J. Locascio, H Li, Niket Gowravaram, RJ Green, Ksenia V. Kastanenka, Brian J. Bacskai, Bradley T. Hyman, Stephen N. Gomperts
This study shows amyloid plaques in the hippocampus cause long-range circuit reorganization in freely behaving mice, affecting place cell distribution and functional maps.
bioRxiv · Apr 27, 2026 · PreprintNeuroscience